A University Course to Facilitate the Transition Into, Through, and Beyond College Life

The purpose of this project was to review the literature associated with the social and psychological adjustments freshmen and transfer intercollegiate athletes face as they transition into college and create a mandatory course to assist them through their transition into California Polytechnic State University. This project led to the creation of an academic course that will be offered at California Polytechnic State University in the near future. This course could serve as an impetus for coaches, faculty, and administrators at other universities to develop similar courses, or reevaluate established course offerings, and to develop follow-up course training for intercollegiate athletes that will contribute to their positive growth throughout the course of their college careers

Experimental Assessment of Cuff Pressures on the Walls of a Trachea-Like Model Using Force Sensing Resistors: Insights for Patient Management in Intensive Care Unit Settings

The COVID-19 outbreak has increased the incidence of tracheal lesions in patients who underwent invasive mechanical ventilation. We measured the pressure exerted by the cuff on the walls of a test bench mimicking the laryngotracheal tract. The test bench was designed to acquire the pressure exerted by endotracheal tube cuffs inflated inside an artificial model of a human trachea. The experimental protocol consisted of measuring pressure values before and after applying a maneuver on two types of endotracheal tubes placed in two mock-ups resembling two different sized tracheal tracts. Increasing pressure values were used to inflate the cuff and the pressures were recorded in two different body positions. The recorded pressure increased proportionally to the input pressure. Moreover, the pressure values measured when using the non-armored (NA) tube were usually higher than those recorded when using the armored (A) tube. A periodic check of the cuff pressure upon changing the body position and/or when performing maneuvers on the tube appears to be necessary to prevent a pressure increase on the tracheal wall. In addition, in our model, the cuff of the A tube gave a more stable output pressure on the tracheal wall than that of the NA tube

Effects of GABA B receptor agonists and antagonists on glycemia regulation in mice

γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABAB receptors in pancreatic β-cells. We investigated whether GABAB receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABAB receptor agonist baclofen (7.5 mg/kg, i.p.) presented glucose intolerance and diminished insulin secretion during a glucose tolerance test (GTT, 2 g/kg body weight, i.p.). The GABAB receptor antagonist 2-hydroxysaclofen (15 mg/kg, i.p.) improved the GTT and reversed the baclofen effect. Also a slight increase in insulin secretion was observed with 2-hydroxysaclofen. In incubated islets 1.10−5 M baclofen inhibited 20 mM glucose-induced insulin secretion and this effect was reversed by coincubation with 1.10−5 M 2-hydroxysaclofen. In chronically-treated animals (18 days) both the receptor agonist (5 mg/kg/day i.p.) and the receptor antagonist (10 mg/kg/day i.p.) induced impaired GTTs; the receptor antagonist, but not the agonist, also induced a decrease in insulin secretion. No alterations in insulin tolerance tests, body weight and food intake were observed with the treatments. In addition glucagon, insulin-like growth factor I, prolactin, corticosterone and growth hormone, other hormones involved in glucose metabolism regulation, were not affected by chronic baclofen or 2-hydroxysaclofen. In islets obtained from chronically injected animals with baclofen, 2-hydroxysaclofen or saline (as above), GABAB2 mRNA expression was not altered. Results demonstrate that GABAB receptors are involved in the regulation of glucose homeostasis in vivo. Treatment with receptor agonists or antagonists, given acutely or chronically, altered glucose homeostasis and insulin secretion alerting to the need to evaluate glucose metabolism during the clinical use of these drugs.Fil: Bonaventura, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Crivello, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ferreira, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Repetto, Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Cymeryng, Cora Betriz. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lux Lantos, Victoria A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Il progetto OnToMap: costruire conoscenza territoriale attraverso l’uso di un’applicazione ICT

Il progetto OnToMap - Mappe di Comunità 3.0 nasce con l'obiettivo di sviluppare uno strumento capace di rispondere alle esigenze informative dei cittadini e di favorire il confronto tra questi e gli amministratori locali, creando uno spazio in cui le relazioni tra gli attori si articolino su una base cartografica e siano favorite dall'uniformità di linguaggio garantita dall'ontologia territoriale, nucleo della piattaforma. Il progetto si sviluppa a partire dalla costruzione di un'ontologia per la rappresentazione della conoscenza territoriale, realizzata attraverso l'individuazione dei concetti che compongono il territorio e l'identificazione delle relazioni semantiche che intercorrono tra essi. In questa prospettiva sono individuate le dimensioni costitutive del territorio, che tengono conto delle componenti ambientali, urbanistiche, culturali e sociali. Il principale risultato del progetto è l'applicazione web OnToMap per la gestione di mappe di comunità interattive. OnToMap è disponibile online, anche in versione mobile, e offre agli utenti internet un punto di vista integrato sul territorio, arricchibile secondo un modello di crowdsourcing e navigabile secondo criteri di ricerca semantici. La ricerca, tuttora in corso, si concentra su una sperimentazione dell'applicazione con lo scopo di produrre mappe partecipate su porzioni territoriali puntuali all'interno del contesto Torinese. In futuro OnToMap sarà arricchito, al fine di contribuire all'empowerment della cittadinanza, con nuove funzionalità; per esempio sarà possibile l'inserimento di nuovi dati da parte dell'utente, l'effettuazione di ricerche di informazioni per parola chiave, il supporto al ragionamento sui vincoli normativi che regolano il territorio e la creazione di forum di discussion